Vitamin D Gene Variants and Multiple Sclerosis in Greece
Author Information
Author(s): Sioka Chrissa, Papakonstantinou Stylianos, Markoula Sofia, Gkartziou Foteini, Georgiou Athanasia, Georgiou Ioannis, Pelidou Sygliti-Henrietta, Kyritsis Athanassios P, Fotopoulos Andreas
Primary Institution: University Hospital of Ioannina
Hypothesis
Are the Taq-I and Bsm-I polymorphisms of the vitamin D receptor gene associated with multiple sclerosis risk and bone mineral density?
Conclusion
The study found no association between the Taq-I and Bsm-I polymorphisms of the vitamin D receptor gene and multiple sclerosis risk or bone mineral density in the Greek population studied.
Supporting Evidence
- No significant differences in Taq-I and Bsm-I genotypes were found between MS patients and controls.
- The study included a total of 150 participants, with 69 MS patients and 81 controls.
- Statistically significant differences were observed only in hip BMD between patients and controls.
Takeaway
The study looked at two specific gene changes related to vitamin D in people with multiple sclerosis and found that these changes don't seem to affect their risk of getting the disease or their bone health.
Methodology
The study involved genotyping of Taq-I and Bsm-I polymorphisms in 69 MS patients and 81 matched controls, along with assessments of BMI, BMD, and smoking history.
Limitations
The study may not be generalizable to other populations due to its specific regional focus.
Participant Demographics
69 MS patients and 81 age and sex-matched healthy individuals.
Statistical Information
P-Value
p<0.001 for hip BMD comparison
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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