Low-Grade Adenosquamous Carcinoma of the Breast: A Study and Literature Review
Author Information
Author(s): Tamminen Anselm, Boström Pia
Primary Institution: Turku University Hospital
Hypothesis
Is low-grade adenosquamous carcinoma (LGASC) a distinct entity that requires different treatment approaches compared to other metaplastic breast carcinomas?
Conclusion
Low-grade adenosquamous carcinoma (LGASC) is a rare and indolent subtype of breast cancer with an excellent prognosis, and it should be treated conservatively to avoid overtreatment.
Supporting Evidence
- LGASC accounts for less than 0.05% of breast cancer cases.
- Three cases of LGASC were diagnosed among 6462 breast cancer patients in the study.
- LGASC is often misdiagnosed due to its overlap with benign sclerosing lesions.
Takeaway
Low-grade adenosquamous carcinoma is a rare type of breast cancer that usually doesn't spread and can often be treated with less aggressive methods.
Methodology
This study involved a single-center retrospective analysis of LGASC patients treated between 2010 and 2022, along with a systematic literature review.
Potential Biases
Potential for misdiagnosis due to overlap with benign lesions and reliance on limited case data.
Limitations
The rarity of LGASC makes it difficult to establish clear treatment guidelines, and much of the existing literature is based on case reports.
Participant Demographics
Patients diagnosed with LGASC were predominantly postmenopausal women aged 50 years or older, but some were younger, including a 19-year-old.
Statistical Information
Confidence Interval
0.01–0.014%
Digital Object Identifier (DOI)
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