Antibiotics for Preterm Labor
Author Information
Author(s): D. Heather Watts, Marijane A. Krohn, Sharon L. Hillier, David A. Eschenbach
Primary Institution: University of Washington
Hypothesis
Does antibiotic therapy plus tocolysis prolong pregnancy in women in preterm labor compared to tocolysis alone?
Conclusion
Antibiotic therapy did not prolong pregnancy duration in women with preterm labor, but it reduced postpartum infections.
Supporting Evidence
- Women receiving antibiotics had a significantly lower incidence of postpartum infections compared to the placebo group.
- No significant differences in the interval to delivery, birth weight, and neonatal outcomes were observed between the two groups.
- Patients with evidence of upper genital tract infection had a significantly shorter interval to delivery.
Takeaway
The study tested if giving antibiotics to pregnant women in early labor could help them stay pregnant longer, but it didn't work, although it did help prevent infections after delivery.
Methodology
A randomized, double-blind trial comparing intravenous mezlocillin and oral erythromycin to placebo in women with preterm labor.
Potential Biases
Potential selection bias in enrolling women at high risk for infection.
Limitations
The study included women without infections, which may have obscured potential benefits of antibiotics.
Participant Demographics
Women aged 15-45 years with singleton gestation and intact membranes, presenting with preterm contractions.
Statistical Information
P-Value
0.03
Confidence Interval
95% CI 0.37-1.5
Statistical Significance
p<0.05
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