The Proinsulin C-peptide--A Multirole Model
2004
The Role of C-Peptide in Insulin Biosynthesis
publication
Evidence: moderate
Author Information
Author(s): Donald F. Steiner
Primary Institution: Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, University of Chicago
Hypothesis
The C-peptide plays multiple roles in the biosynthesis and function of insulin.
Conclusion
The C-peptide is essential for the proper folding and assembly of insulin and may have additional physiological roles.
Supporting Evidence
- The C-peptide is released in equimolar amounts with insulin, making it a useful indicator of insulin secretion.
- Mutations in the C-peptide can affect the folding properties of proinsulin.
- The C-peptide has been shown to influence insulin assembly and stability.
Takeaway
C-peptide helps insulin get made correctly in the body and might do other important things too.
Methodology
This is a review article summarizing existing research on the C-peptide's roles in insulin biosynthesis.
Limitations
The review does not present new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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