Cyclin A Score Predicts Chemotherapy Response in Soft Tissue Sarcoma
Author Information
Author(s): Huuhtanen R L, Wiklund T A, Blomqvist C P, Böhling T O, Virolainen M J, Tribukait B, Andersson L C
Primary Institution: Helsinki University Central Hospital
Hypothesis
Can the proliferation rate measured by cyclin A predict chemotherapy response in soft tissue sarcoma patients?
Conclusion
A high cyclin A score is associated with a better response to chemotherapy in soft tissue sarcoma patients.
Supporting Evidence
- A high cyclin A score correlates with better chemotherapy response.
- S phase fraction and Ki-67 score did not predict chemotherapy response.
Takeaway
Doctors can use a test called cyclin A to see if patients with soft tissue sarcoma will respond well to chemotherapy.
Methodology
The study measured the proliferation rate of primary tumors using flow cytometric S phase fraction and immunohistochemical scores for Ki-67 and cyclin A.
Limitations
The study does not address the majority of patients who do not benefit from therapy.
Participant Demographics
Patients with locally advanced or metastatic soft tissue sarcoma.
Statistical Information
P-Value
P = 0.02 for chemotherapy response; P = 0.04 for progression-free survival.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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