Link Between Phenotypic Age and Mortality Risk in Obese Individuals
Author Information
Author(s): Huang Yingxuan, Zhou Apei, Huang Yisen, Wang Yubin, Liu Xiaobo, Liu Xiaoqiang
Primary Institution: First Hospital of Quanzhou Affiliated to Fujian Medical University
Hypothesis
This study investigates the association between phenotypic age acceleration (PAA) and all-cause and cause-specific mortality in obese individuals.
Conclusion
PAA is an independent predictor of all-cause, cardiovascular, and cancer mortality in obese individuals.
Supporting Evidence
- PAA was significantly associated with all-cause mortality (HR = 1.84).
- PAA was significantly associated with cardiovascular mortality (HR = 1.86).
- PAA was significantly associated with cancer mortality (HR = 1.47).
- 1,537 deaths were recorded during a median follow-up of 10.6 years.
- Participants with PAA had a higher mean age compared to those without PAA.
Takeaway
The study found that people with obesity who age faster biologically are more likely to die from various causes, showing that how we age can affect our health.
Methodology
Data were drawn from NHANES, including 9,925 obese adults, and analyzed using survival analysis and Cox proportional hazards models.
Potential Biases
Unmeasured confounders may still influence the results despite adjustments for multiple variables.
Limitations
The study's PAA calculation was based on a one-time measurement and may not capture dynamic changes in physiological states.
Participant Demographics
Participants were obese adults with a mean age of 50.9 years, including various races and socioeconomic statuses.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 1.64–2.06
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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