Study on PTGS2 Gene and Breast Cancer Risk
Author Information
Author(s): David G. Cox, Julie Buring, Susan E. Hankinson, David J. Hunter
Primary Institution: Harvard School of Public Health
Hypothesis
Polymorphisms in the PTGS2 gene are associated with breast cancer risk.
Conclusion
The rs5275 polymorphism in the PTGS2 gene may be associated with a decrease in breast cancer risk among Caucasian women.
Supporting Evidence
- The rs5275 polymorphism was associated with a 20% lower risk of breast cancer.
- No significant heterogeneity in risk estimates was observed between studies.
- Pooled analyses showed a statistically significant trend of decreasing risk with each variant rs5275 allele.
Takeaway
This study looked at a gene that might affect breast cancer risk and found that one specific change in the gene could lower the risk of getting breast cancer.
Methodology
Genotyping of five common polymorphisms in the PTGS2 gene using logistic regression analyses in nested case-control studies.
Potential Biases
Potential bias in self-reported data and matching criteria for controls.
Limitations
The study primarily involved Caucasian women, which may limit the generalizability of the findings.
Participant Demographics
Cohorts primarily consisted of Caucasian women from the Nurses' Health Study.
Statistical Information
P-Value
0.02
Confidence Interval
0.66 to 0.97
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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