Variation in host susceptibility and infectiousness generated by co-infection: the myxoma–Trichostrongylus retortaeformis case in wild rabbits
2007

How Co-Infection Affects Rabbit Health

Sample size: 864 publication 10 minutes Evidence: high

Author Information

Author(s): Cattadori Isabella M, Albert Réka, Boag Brian

Primary Institution: The University of Glasgow

Hypothesis

How does myxoma infection alter host susceptibility to the nematode Trichostrongylus retortaeformis in wild rabbits?

Conclusion

Myxoma infections increase host susceptibility to the nematode, leading to higher worm intensity and longer infectious periods.

Supporting Evidence

  • Myxoma co-infection led to higher T. retortaeformis intensity in rabbits.
  • Co-infected rabbits remained infectious for longer periods.
  • Age-related patterns of infection were observed in the rabbit population.

Takeaway

When rabbits get infected with both a virus and a worm, they can get sicker and spread the worm more easily.

Methodology

The study used a demographic infection–immunity model based on field data collected over 26 years.

Potential Biases

Potential misclassification of disease due to the evolution of myxoma virulence over time.

Limitations

The study did not explicitly measure the time delay between nematode and virus infection.

Participant Demographics

The study focused on male European rabbits (Oryctolagus cuniculus) of various age classes.

Statistical Information

P-Value

p<0.001

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1098/rsif.2007.1075

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