Serum A-FABP Levels and Coronary Artery Disease in Chinese Women
Author Information
Author(s): Bao Yuqian, Lu Zhigang, Zhou Mi, Li Huating, Wang Ye, Gao Meifang, Wei Meng, Jia Weiping
Primary Institution: Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Hypothesis
This study investigates the relationship between serum levels of A-FABP and the presence and severity of coronary artery disease (CAD) in Chinese subjects.
Conclusion
Serum A-FABP is closely associated with the presence and severity of CAD in Chinese women.
Supporting Evidence
- A-FABP levels in patients with CAD were significantly higher compared with non-CAD subjects.
- Serum A-FABP increased significantly in multi-vessel diseased patients than in non-CAD subjects.
- Serum A-FABP was an independent risk factor for CAD in women.
Takeaway
This study found that higher levels of a protein called A-FABP in the blood are linked to more severe heart disease in women.
Methodology
Circulating A-FABP level was determined by ELISA in 341 Chinese subjects who underwent coronary angiography.
Potential Biases
The study only included subjects admitted for coronary angiography, which may not represent the general population.
Limitations
The sample size was not large enough, and the study's cross-sectional design does not allow for cause-effect relationships to be determined.
Participant Demographics
341 participants (221 men, 120 women, aged 66.1±10.4 years), all women were postmenopausal.
Statistical Information
P-Value
0.021
Confidence Interval
95%CI: 1.299-24.457
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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