Immunodetectable cyclin D 1 is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions
2001
Cyclin D1 and Its Relationship with Estrogen Receptor in Breast Lesions
publication
Author Information
Author(s): Shoker B S, Jarvis C, Davies M P A, Iqbal M, Sibson D R, Sloane J P
Primary Institution: Dept. of Pathology, Royal Liverpool University Hospital
Hypothesis
The study aims to determine the interplay between estrogen receptor, Ki67, and cyclin D1 in breast lesions.
Conclusion
Cyclin D1 does not appear to be associated with cell cycle progression in breast lesions but may interact with the estrogen receptor.
Supporting Evidence
- There is a strong positive association between estrogen receptor and cyclin D1 expression in normal breast.
- A strong negative association exists between cyclin D1 and Ki67 expression.
Takeaway
The study found that cyclin D1 is linked to the estrogen receptor in breast tissue, but it doesn't help cells divide.
Methodology
The study used dual staining immunofluorescence to analyze breast lesions.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website