The Role of PRMT1 Gene in Colon Cancer
Author Information
Author(s): Mathioudaki K, Papadokostopoulou A, Scorilas A, Xynopoulos D, Agnanti N, Talieri M
Primary Institution: ‘G Papanicolaou’ Research Center of Oncology, ‘Saint Savvas’ Hospital, Athens, Greece
Hypothesis
The expression pattern of the PRMT1 gene is associated with clinical and histological parameters in colon cancer patients.
Conclusion
High expression of the PRMT1-v1 variant is linked to poor prognosis in colon cancer patients.
Supporting Evidence
- High expression of PRMT1-v1 is associated with advanced TNM stage.
- Patients with high PRMT1-v1 expression have a higher probability of relapse.
- PRMT1-v1 expression levels correlate with clinical and histopathological features.
Takeaway
This study looks at a gene called PRMT1 and how its levels can help doctors understand how serious colon cancer is.
Methodology
The study analyzed PRMT1 expression in colon cancer tissues using semiquantitative RT–PCR and immunohistochemistry.
Limitations
The study is limited by its retrospective design and the need for further validation in larger cohorts.
Participant Demographics
Patients aged 31 to 92 years, mean age 67.45 years.
Statistical Information
P-Value
P=0.005
Confidence Interval
95% CI: 1.35–10.73
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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