Axin and Oesophageal Cancer Progression
Author Information
Author(s): Nakajima M, Fukuchi M, Miyazaki T, Masuda N, Kato H, Kuwano H
Primary Institution: Gunma University Faculty of Medicine
Hypothesis
Is Axin expression a significant prognostic factor in oesophageal squamous cell carcinoma?
Conclusion
Reduced expression of Axin is associated with tumour progression in oesophageal squamous cell carcinoma.
Supporting Evidence
- Axin expression was inversely correlated with depth of invasion and lymphatic invasion.
- Patients with reduced Axin expression had a higher risk of tumour progression.
- Univariate analysis identified Axin negativity as a negative predictor of survival.
Takeaway
This study found that when a protein called Axin is less present in cancer cells, it can mean the cancer is getting worse.
Methodology
The study examined Axin expression in tumour samples using immunohistochemistry and analyzed patient data for correlations with clinical outcomes.
Limitations
The study did not include patients who underwent noncurative surgery or had inadequate follow-up.
Participant Demographics
81 patients (70 males and 11 females) aged 40-78 years, mean age 61.3 years.
Statistical Information
P-Value
0.0058
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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