Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer
Author Information
Author(s): Popat Sanjay, Wort Richard, Houlston Richard S
Primary Institution: Institute of Cancer Research
Hypothesis
We sought to investigate whether relationships exist between these markers that might contribute to CRC phenotypes.
Conclusion
Relationships exist between p53 status and TS expression, and MSI and p53 status, which may contribute to the clinical phenotypes of CRCs.
Supporting Evidence
- 244 tumours (55%) over-expressed p53.
- 259 (58%) expressed high TS levels.
- 65 tumours (15%) had MSI.
- A significant relationship between p53 over-expression and high TS expression was observed (p = 0.01).
- A highly significant inverse relationship between MSI and p53 status was observed (p = 0.001).
- No relationship was seen between MSI status and TS expression (p = 0.59).
Takeaway
This study looked at how three markers in colorectal cancer are related to each other and how they might affect the cancer's behavior.
Methodology
The study assessed p53 status and TS expression using immunohistochemistry and determined mismatch repair status by microsatellite instability genotyping.
Limitations
The small number of tumours with MSI may limit the generalizability of the findings.
Participant Demographics
Patients with stage I-III colorectal cancer.
Statistical Information
P-Value
p = 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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