Myd88's Role in Antibody Response to Retroviral Infection
Author Information
Author(s): Browne Edward P., Littman Dan R.
Primary Institution: New York University School of Medicine
Hypothesis
Myd88 is required for the generation of an antibody response during retroviral infection.
Conclusion
Myd88 is essential for the generation of neutralizing antibodies against the Friend murine leukemia virus.
Supporting Evidence
- Specific deletion of dendritic cells during F-MLV infection caused a significant increase in viral titers.
- Myd88 knockout mice failed to control F-MLV and sustained high viral titers for several months.
- Passive transfer of immune serum from wild-type mice to Myd88 knockout mice rescued control of F-MLV.
Takeaway
Myd88 helps the body make antibodies to fight off certain viruses, like the Friend virus, which is important for developing vaccines.
Methodology
The study used Myd88 knockout mice and CD11c+ dendritic cell-depleted mice to assess immune responses to F-MLV infection.
Potential Biases
Potential bias in the interpretation of results due to the specific mouse models used.
Limitations
The study primarily focused on a single retrovirus and may not generalize to all retroviral infections.
Participant Demographics
Mice used were primarily C57BL/6 and Myd88 knockout strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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