Stenotrophomonas maltophilia in Cystic Fibrosis Patients
Author Information
Author(s): Sylvia Valdezate, Ana Vindel, Luis Maiz, Fernando Baquero, Hector Escobar, Rafael Canton
Primary Institution: Hospital Ramon y Cajal, Madrid, Spain
Hypothesis
What is the incidence and role of Stenotrophomonas maltophilia in cystic fibrosis patients?
Conclusion
The study found a high incidence of Stenotrophomonas maltophilia colonization in cystic fibrosis patients, with significant differences in bacterial counts and age of acquisition between those with single and repeated episodes.
Supporting Evidence
- Overall incidence of S. maltophilia infection or colonization was 24% among cystic fibrosis patients.
- Patients with repeated episodes had higher bacterial counts than those with a single episode.
- Chronic colonization occurred more frequently in older patients.
Takeaway
This study looked at how a germ called Stenotrophomonas maltophilia affects kids with cystic fibrosis. They found that older kids are more likely to get it and that it can stick around for a long time.
Methodology
The study analyzed respiratory isolates from 25 cystic fibrosis patients over an 8-year period, using molecular typing, ribotyping, and pulsed-field gel electrophoresis.
Limitations
The small sample size may limit the generalizability of the findings.
Participant Demographics
Patients aged <1 to 32 years, with a median age of 14.5 years; 12 females and 13 males.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
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