Impact of Early Upper Limb Stimulation in Stroke Recovery
Author Information
Author(s): Kwakkel Gert, Meskers Carel GM, van Wegen Erwin E, Lankhorst Guus J, Geurts Alexander CH, van Kuijk Annet A, Lindeman Eline, Visser-Meily Anne, de Vlugt Erwin, Arendzen J Hans
Primary Institution: VU University Medical Centre
Hypothesis
Is an early modified CIMT programme more effective in terms of recovery of the paretic upper limb than conventional care in stroke patients with a favourable prognosis for recovery of the upper limb?
Conclusion
The EXPLICIT-stroke programme aims to investigate the effects of early applied intensive intervention for regaining dexterity and explore the underlying mechanisms involved in regaining upper limb function after stroke.
Supporting Evidence
- 80% of stroke survivors have upper limb paresis immediately after stroke onset.
- Functional outcome at 6 months is highly predictable within a critical time window of 4 weeks post stroke.
- Recent studies suggest that early return of wrist and finger extension is key for regaining dexterity.
Takeaway
This study is trying to find out if starting therapy early after a stroke helps people use their arms better. They will test different treatments to see which one works best.
Methodology
The study includes two randomized single-blinded trials with 180 participants, comparing modified CIMT and EMG-NMS against usual care.
Potential Biases
Potential biases may arise from the randomization process and the subjective nature of some assessments.
Limitations
The study may not account for all variables affecting recovery, and the results may not be generalizable to all stroke patients.
Participant Demographics
Participants are first-ever ischemic stroke patients aged 18-80, with varying prognoses for recovery.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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