Multiple Vaccinations with UV-Attenuated Cercariae in Pigs
Author Information
Author(s): Lin Dandan, Tian Fang, Wu Haiwei, Gao Yanan, Wu Jingjiao, Zhang Donghui, Ji Minjun, McManus Donald P, Driguez Patrick, Wu Guanling
Primary Institution: Nanjing Medical University
Hypothesis
Does multiple vaccinations with UV-attenuated cercariae provide better protection against Schistosoma japonicum infection compared to a single vaccination?
Conclusion
Three vaccinations with a UV-attenuated vaccine provide significantly better protection against S. japonicum infection in pigs than a single vaccination.
Supporting Evidence
- Single vaccination resulted in a 59.33% reduction in adult worm burden.
- Triple vaccinations led to a 77.62% reduction in adult worms.
- Triple vaccinations resulted in a 99.78% reduction in fecal eggs.
Takeaway
Pigs that got three shots of a special vaccine were much better protected from a disease than those that only got one shot.
Methodology
Pigs were vaccinated with either one or three doses of UV-attenuated cercariae and then challenged with normal cercariae to assess protection levels.
Potential Biases
Potential bias in the selection of pigs and the challenge method.
Limitations
The study did not assess long-term immunity beyond the 8-week post-challenge period.
Participant Demographics
Landrace/Yorkshire/Duroc crossbred pigs, 18-20 kg, male.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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