Cigarette Smoking and Endometrial Cancer Risk
Author Information
Author(s): Terry P D, Miller A B, Rohan T E
Primary Institution: Albert Einstein College of Medicine
Hypothesis
What is the association between cigarette smoking and the risk of endometrial cancer?
Conclusion
Current smokers who smoke 20 cigarettes per day or more have a reduced risk of endometrial cancer.
Supporting Evidence
- 403 women were diagnosed with incident endometrial cancer during the study.
- Current smokers had a 23% reduced risk of endometrial cancer after adjusting for age.
- The association was stronger among parous women compared to nulliparous women.
- Follow-up averaged 10.6 years, yielding 751,833 person-years of data.
- Women who smoked 20 cigarettes per day or more had a hazard ratio of 0.62.
Takeaway
Women who smoke a lot of cigarettes might have a lower chance of getting a certain type of cancer called endometrial cancer.
Methodology
The study used proportional hazards models to estimate hazard ratios relating cigarette smoking to endometrial cancer risk among women in a large prospective cohort.
Potential Biases
There is a potential risk of bias due to differential follow-up of smokers compared to non-smokers.
Limitations
The study did not have information on hysterectomy occurrence during follow-up, which could bias results.
Participant Demographics
Women aged 40-59 years at recruitment, with a total of 70,591 participants.
Statistical Information
P-Value
0.03
Confidence Interval
0.42–0.92
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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