Role of Smac/DIABLO in cancer progression
2008
Role of Smac/DIABLO in Cancer Progression
publication
Evidence: moderate
Author Information
Author(s): Gustavo Martinez-Ruiz, Vilma Maldonado, Gisela Ceballos-Cancino, Juan P Reyes Grajeda, Jorge Melendez-Zajgla
Primary Institution: National Institute of Genomic Medicine
Hypothesis
The expression levels of Smac/DIABLO could be negatively regulated during the initiation or progression of cancer.
Conclusion
Smac/DIABLO expression inversely correlates with cancer progression and aggressive behavior, indicating its potential as a prognostic marker.
Supporting Evidence
- Lower Smac/DIABLO levels are associated with worse prognosis in various cancers.
- Patients with metastatic disease had lower Smac/DIABLO levels than those with localized disease.
- Smac/DIABLO expression is reduced in hepatocellular carcinoma compared to normal tissue.
Takeaway
Smac/DIABLO helps cancer cells die when they should, and lower levels of it can make cancer more aggressive and harder to treat.
Limitations
The review summarizes various studies but does not provide new experimental data.
Digital Object Identifier (DOI)
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