GDNF Secreting Human Neural Progenitor Cells Protect Motor Neurons in ALS Model
Author Information
Author(s): Suzuki Masatoshi, McHugh Jacalyn, Tork Craig, Shelley Brandon, Klein Sandra M., Aebischer Patrick, Svendsen Clive N.
Primary Institution: The Waisman Center, University of Wisconsin-Madison
Hypothesis
Can genetically modified human neural progenitor cells that secrete GDNF protect motor neurons in a rat model of familial ALS?
Conclusion
The study found that GDNF-secreting human neural progenitor cells can significantly protect motor neurons from degeneration in a rat model of ALS, but do not improve muscle innervation or limb function.
Supporting Evidence
- GDNF-secreting cells significantly increased motor neuron survival in the spinal cord.
- Transplanted cells migrated into degenerating areas and released GDNF.
- Motor neuron protection was observed even at the end stages of the disease.
Takeaway
Scientists used special cells that make a protein called GDNF to help sick nerve cells in rats stay alive longer, but the rats still couldn't move their legs better.
Methodology
The study involved genetically modifying human neural progenitor cells to release GDNF and transplanting them into the spinal cords of SOD1G93A rats.
Limitations
The study did not assess the long-term effects of the treatment on muscle innervation and limb function.
Participant Demographics
Female SOD1G93A rats were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website