Plasma Osteoprotegerin and Cardiovascular Disease in Type 2 Diabetes
Author Information
Author(s): Mikael K Poulsen, Mads Nybo, Jordi Dahl, Susanne Hosbond, Tina S Poulsen, Allan Johansen, Poul F Høilund-Carlsen, Henning Beck-Nielsen, Lars M Rasmussen, Jan E Henriksen
Primary Institution: Odense University Hospital, Odense, Denmark
Hypothesis
What is the relationship between plasma osteoprotegerin levels and cardiovascular disease manifestations in type 2 diabetes patients?
Conclusion
Increased plasma osteoprotegerin concentration is associated with carotid and peripheral arterial disease in patients with type 2 diabetes, but not with myocardial ischemia.
Supporting Evidence
- Plasma OPG was significantly increased in patients with carotid and peripheral arterial disease compared to those without.
- The prevalence of carotid arterial disease was 42%, peripheral arterial disease was 15%, and myocardial ischemia was 30%.
- Plasma OPG levels were associated with carotid arterial disease after adjusting for age, HbA1c, and U-albumin creatinine ratio.
Takeaway
This study found that higher levels of a protein called osteoprotegerin in the blood are linked to certain types of blood vessel problems in people with diabetes, but not to heart problems.
Methodology
Patients with type 2 diabetes were screened for carotid arterial disease, peripheral arterial disease, and myocardial ischemia using various imaging techniques and blood tests.
Limitations
126 out of 431 eligible patients refused to participate or did not show up, which may introduce selection bias.
Participant Demographics
Patients were type 2 diabetes individuals, average age 58.6 years, with a diabetes duration of 4.5 years.
Statistical Information
P-Value
p = 0.008
Confidence Interval
95% CI: 1.22-3.67
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website