NMDA Receptors and Synaptic Competition in Neurons
Author Information
Author(s): Kevin She, Craig Ann Marie
Primary Institution: University of British Columbia
Hypothesis
Can NMDA receptor activity influence synaptic competition in cultured hippocampal neurons?
Conclusion
NMDA receptor activity is essential for enhanced synaptic density in minority wild type neurons competing with majority GluN1 -/- neurons.
Supporting Evidence
- NMDA receptor activity was required for enhanced synapse density in minority wild type neurons.
- Synapse density did not differ significantly in equal co-cultures of wild type and GluN1 -/- neurons.
- Chronic blockade of NMDA receptors abolished differences in synapse density.
Takeaway
This study shows that neurons with NMDA receptors can grow more connections when they are outnumbered by neurons without these receptors.
Methodology
Hippocampal neurons from GluN1 -/- and wild type mice were cultured in various ratios to assess synaptic density.
Limitations
The study is limited to in vitro conditions and may not fully represent in vivo synaptic competition.
Participant Demographics
Hippocampal neurons from GluN1 -/- and wild type mice.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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