Propofol Infusion and Fungal Resistance
Author Information
Author(s): Costa-de-Oliveira Sofia, Araujo Ricardo, Silva-Dias Ana, Pina-Vaz Cidália, Rodrigues Acácio Gonçalves
Primary Institution: Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal
Hypothesis
Does propofol lipidic infusion affect the growth and antifungal susceptibility of pathogenic fungi?
Conclusion
Propofol infusion increases fungal germination and promotes resistance to antifungals due to reduced access to the drugs.
Supporting Evidence
- Propofol infusion promoted budding of Candida and germination of Aspergillus.
- All antifungal MFC values increased when incubated with propofol.
- A significant reduction in intracellular uptake of itraconazole was observed with propofol treatment.
Takeaway
When doctors use a drug called propofol, it can make some fungi stronger against medicines that usually kill them.
Methodology
The study evaluated the effect of propofol on Candida and Aspergillus strains using flow cytometry and radioactivity assays.
Limitations
MIC values could not be determined due to the opacity of propofol infusion.
Participant Demographics
Twenty clinical strains of Candida spp. and thirteen strains of Aspergillus spp. were studied.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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