Study of Zindoxifene for Advanced Breast Cancer
Author Information
Author(s): R.C. Stein, M. Dowsett, D.C. Cunningham, J. Davenport, H.T. Ford, J.-C. Gazet, E. von Angerer, R.C. Coombes
Primary Institution: St. George's Hospital Medical School
Hypothesis
Does zindoxifene have therapeutic activity in the treatment of advanced breast cancer?
Conclusion
Zindoxifene has only marginal therapeutic activity in the treatment of advanced breast cancer.
Supporting Evidence
- Twenty-five patients were assessed for response, with no objective responses observed.
- Seven patients experienced disease stabilization for up to 5 months.
- Five patients responded to subsequent endocrine therapy after zindoxifene treatment.
Takeaway
Doctors tested a new medicine called zindoxifene on women with advanced breast cancer, but it didn't help them get better.
Methodology
The study treated 28 post-menopausal women with advanced breast cancer using varying doses of zindoxifene and assessed their responses.
Potential Biases
The phase I nature of the study may have introduced bias due to the inclusion of patients with low probability of response.
Limitations
The study included patients who were unlikely to respond to zindoxifene, which may have affected the results.
Participant Demographics
Participants were post-menopausal women aged 48-90, with varying ER status.
Statistical Information
P-Value
<0.001
Confidence Interval
95%
Statistical Significance
p<0.001
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