HPV Genotype Distribution in Czech Patients with HPV-Related Diseases
Author Information
Author(s): Tachezy Ruth, Smahelova Jana, Salakova Martina, Arbyn Marc, Rob Lukas, Skapa Petr, Jirasek Tomas, Hamsikova Eva
Primary Institution: Institute of Hematology and Blood Transfusion, Department of Experimental Virology, Prague, Czech Republic
Hypothesis
What is the type-specific HPV prevalence in Czech women and men with anogenital diseases?
Conclusion
The prevalence of vaccinal and related HPV types in patients with HPV-associated diseases in the Czech Republic is very high.
Supporting Evidence
- HPV 16 was the most prevalent type in both precancerous lesions (45%) and squamous cell carcinomas (59%).
- 61% of carcinoma samples contained HPV 16 and/or 18.
- 76% of cervical cancer samples contained HPV 16 and/or 18.
- HPV types related to the vaccinal ones were detected in 16% of carcinoma samples.
Takeaway
This study looked at how common different types of HPV are in people with certain diseases in the Czech Republic, finding that many have types that vaccines can protect against.
Methodology
The study analyzed 157 squamous cell carcinoma samples, 695 precancerous lesion samples, and 64 condylomata acuminate samples using PCR and reverse line blot hybridization.
Potential Biases
Potential biases may arise from the selection of samples from specific hospitals and the retrospective nature of the study.
Limitations
The study's findings may not be generalizable beyond the Czech population and were based on historical samples collected between 1993 and 2005.
Participant Demographics
The study included both men and women with a range of ages, with specific mean ages reported for different conditions.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 1.4–1.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website