Comparative genomic hybridization and histological variation in primitive neuroectodermal tumours
1999
Genetic Changes in Brain Tumors
Sample size: 37
publication
Evidence: moderate
Author Information
Author(s): Nicholson J C, Ross F M, Kohler J A, Ellison D W
Primary Institution: Wessex Regional Genetics Laboratory, Salisbury, Wiltshire, UK
Hypothesis
Chromosomal imbalances in central nervous system primitive neuroectodermal tumours (PNETs) reflect site and histology.
Conclusion
The study found significant associations between tumour variants and genetic abnormalities in medulloblastomas.
Supporting Evidence
- Chromosomal imbalances were detected in 28 medulloblastomas (90%).
- Aberrations suggesting isochromosome 17q were present in eight (26%) medulloblastomas.
- Loss on 9q was found in six cases (19%), five of them nodular/desmoplastic.
- Different patterns of imbalance were found in the cerebral PNETs.
Takeaway
This study looked at brain tumors and found that different types of tumors have different genetic changes.
Methodology
Comparative genomic hybridization was used to study 37 cases of PNET.
Participant Demographics
The study included 37 cases, with 4 cerebral PNETs and 31 medulloblastomas classified as classic or nodular/desmoplastic.
Digital Object Identifier (DOI)
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