Prognostic Value of c-myc in Breast Cancer
Author Information
Author(s): Scorilas A, Trangas T, Yotis J, Pateras C, Talieri M
Primary Institution: G Papanikolaou Research Center of Oncology
Hypothesis
The study investigates the prognostic value of c-myc amplification and overexpression in breast cancer patients compared to other factors.
Conclusion
C-myc amplification and overexpression are significant for predicting disease-free and overall survival in breast cancer, but cathepsin-D concentration remains the most significant factor after multivariate analysis.
Supporting Evidence
- C-myc amplification and overexpression were highly significant for disease-free survival.
- C-myc amplification and overexpression showed a tendency for locoregional recurrence.
- Cathepsin-D concentration was the best predictor of early relapse.
Takeaway
This study looked at how certain genes and proteins in breast cancer can help predict how well patients will do. It found that one protein, cathepsin-D, is really important for understanding patient outcomes.
Methodology
The study used univariate and multivariate analysis to evaluate the prognostic significance of c-myc amplification and overexpression in relation to other factors.
Participant Demographics
Breast cancer patients
Statistical Information
P-Value
P = 0.0016 and P = 0.0001 for disease-free survival; P < 0.0001 and P = 0.0095 for overall survival.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website