Biodistribution of Charged Photoimmunoconjugates in Colorectal Cancer
Author Information
Author(s): Hamblin M R, Governatore M Del, Rizvi I, Hasan T
Primary Institution: Wellman Laboratories of Photomedicine, Massachusetts General Hospital, and Department of Dermatology, Harvard Medical School
Hypothesis
The study investigates whether antibody-targeted photosensitizers can improve selectivity for tumours over normal liver tissue in photodynamic therapy.
Conclusion
The anionic 17.1A conjugate delivered significantly more photosensitizer to the tumour compared to other conjugates.
Supporting Evidence
- The anionic 17.1A conjugate delivered more than twice as much photosensitizer to the tumour at 3 hours compared to other species.
- The tumour:normal liver ratio for the anionic conjugate was 2.5.
- Tumour-to-liver ratios were greater than one for most compounds at 3 hours but declined at 24 hours.
- Cationic species had a high uptake in the lungs compared to anionic species.
Takeaway
This study shows that special drugs can be made to better target cancer cells in the liver, helping to treat cancer more effectively.
Methodology
The study used murine models to measure the biodistribution of antibody-targeted photosensitizers by quantifying chlorine6 content in tissue samples.
Participant Demographics
The study used nude mice bearing tumours derived from human colorectal cancer cells.
Digital Object Identifier (DOI)
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