Impact of Intermittent Hypoxia in Aged Mice
Author Information
Author(s): Donega Stefano, McDevitt Ross, Hernandez Rolando, Chisolm Cindy, FIshbein Kenneth, McCart Elizabeth, Wilgenburg Brian, Ferrucci Luigi
Primary Institution: National Institute on Aging, Baltimore, Maryland, United States
Hypothesis
How does intermittent hypoxia affect aging and health in mice?
Conclusion
The study aims to create a comprehensive atlas of how intermittent hypoxia impacts various tissues in aged mice.
Supporting Evidence
- More than 1500 samples were collected from 15 different tissues.
- Mice were exposed to oxygen levels fluctuating from 21% to 5% in cycles.
- The study aims to construct a comprehensive murine IH atlas.
Takeaway
The researchers are studying how low oxygen levels affect older mice to find ways to help them stay healthy.
Methodology
The study involves collecting samples from different tissues of adult and old mice exposed to intermittent hypoxia and conducting various analyses including transcriptomic and epigenetic studies.
Participant Demographics
Adult (9-11 months) and old (20-23 months) mice.
Digital Object Identifier (DOI)
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