Apigenin Inhibits Breast Cancer Cell Growth
Author Information
Author(s): Chen Di, Landis-Piwowar Kristin R, Chen Marina S, Dou Q Ping
Primary Institution: The Prevention Program, Barbara Ann Karmanos Cancer Institute and Department of Pathology, School of Medicine, Wayne State University
Hypothesis
Does apigenin inhibit proteasome activity in breast cancer cells and xenografts?
Conclusion
Apigenin effectively inhibits proteasome activity and induces apoptosis in breast cancer cells and tumors.
Supporting Evidence
- Apigenin inhibited cell viability in a dose-dependent manner.
- Caspase-3/caspase-7 activation indicated apoptosis in treated cells.
- No apparent toxicity was observed in treated mice.
Takeaway
Apigenin, a natural compound found in fruits and vegetables, can help stop breast cancer cells from growing and make them die.
Methodology
MDA-MB-231 breast cancer cells and xenografts were treated with apigenin, followed by assays to measure cell viability, proteasome activity, and apoptosis.
Limitations
The study used high concentrations of apigenin that may not reflect typical dietary intake.
Participant Demographics
Female athymic nude mice were used for in vivo experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website