Drug–Phospholipid Co-Amorphous Formulations: The Role of Preparation Methods and Phospholipid Selection
Author Information
Author(s): Khorami Keyoomars, Farahani Sam Darestani, Müllertz Anette, Rades Thomas
Primary Institution: Department of Pharmacy, Faculty of Health and Medical Science, University of Copenhagen
Hypothesis
This study aims to broaden the knowledge on co-amorphous phospholipid systems (CAPSs) by exploring the formation of CAPSs with a broader range of poorly water-soluble drugs.
Conclusion
The study highlights the critical role of drug selection, preparation method, and phospholipid type in developing stable and effective co-amorphous phospholipid systems.
Supporting Evidence
- SE consistently prepared CAPSs for CCX-PLs, FUR-PLs, and RIT-PLs.
- The stability of each drug varied depending on the phospholipids used.
- CAPSs formed by SE significantly improve the dissolution behavior of CCX and RIT.
Takeaway
This study looks at how to mix certain drugs with phospholipids to make them dissolve better in water, which can help people take their medicine more easily.
Methodology
The CAPSs were prepared using mechano-chemical activation-based, melt-based, and solvent-based methods, and their stability was tested under different humidity conditions.
Limitations
The optimal molar ratio for drug stability remained uncertain, and the study did not explore all possible drug-phospholipid combinations.
Digital Object Identifier (DOI)
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