Hypertension Types and Their Impact on Heart Health
Author Information
Author(s): Tewari Jay, Qidwai Khalid Ahmad, Roy Shubhajeet, Saxena Mehul, Rana Anadika, Tewari Ajoy, Tewari Vineeta, Maheshwari Anuj
Primary Institution: King George’s Medical University, Lucknow, India
Hypothesis
This systematic review and meta-analysis aims to evaluate the relationship between various hypertension phenotypes and future cardiovascular events and all-cause mortality.
Conclusion
Masked hypertension and sustained hypertension are linked to higher cardiovascular mortality compared to normotension.
Supporting Evidence
- Masked hypertension was associated with increased cardiovascular mortality with a pooled HR of 2.05.
- Sustained hypertension also showed a higher risk with a pooled HR of 2.42.
- White coat hypertension did not significantly increase cardiovascular mortality risk with a pooled HR of 1.18.
- Neither masked hypertension nor white coat hypertension showed significant increases in all-cause mortality.
Takeaway
Some types of high blood pressure can be more dangerous than others, and it's important to check blood pressure outside of the doctor's office to find these risks.
Methodology
A systematic review and meta-analysis were conducted following PRISMA, Cochrane, and MOOSE guidelines, analyzing studies that reported associations between hypertension phenotypes and mortality.
Potential Biases
The included studies had a relatively minimal risk of bias.
Limitations
The study included only eight studies, which may limit the generalizability of the findings.
Participant Demographics
Participants included individuals with various hypertension phenotypes, with a mean age ranging from 53 to 70 years and varying percentages of males and diabetes history.
Statistical Information
P-Value
p<0.00001
Confidence Interval
95% CI 1.69–2.48 for masked hypertension and 95% CI 2.12–2.76 for sustained hypertension.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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