Gut Issues in Children with Autism
Author Information
Author(s): Brent L. Williams, Mady Hornig, Timothy Buie, Margaret L. Bauman, Myunghee Cho, Ivan Wick, Ashlee Bennett, Omar Jabado, David L. Hirschberg, W. Ian Lipkin
Primary Institution: Center for Infection and Immunity, Columbia University, New York, New York, United States of America
Hypothesis
How does intestinal gene expression and microbiota composition differ in children with autism compared to those without?
Conclusion
Children with autism show significant deficiencies in intestinal disaccharidases and altered gut microbiota compared to typically developing children.
Supporting Evidence
- 93.3% of children with autism had decreased mRNA levels for at least one disaccharidase.
- Children with autism showed a significant decrease in Bacteroidetes and an increase in Firmicutes.
- Deficiencies in disaccharidases were associated with changes in gut microbiota composition.
Takeaway
Kids with autism might have tummy troubles because their bodies don't break down food the same way, which can change the bacteria in their bellies.
Methodology
The study analyzed intestinal biopsies from children with autism and gastrointestinal issues, comparing gene expression and microbiota composition to control children.
Potential Biases
Potential biases may arise from the reliance on parental reports for dietary and health information.
Limitations
The study had a small sample size and focused only on male children, which may limit the generalizability of the findings.
Participant Demographics
The study included 15 children with autism and gastrointestinal issues and 7 control children, all male.
Statistical Information
P-Value
p=0.001 for SI, p=0.003 for MGAM, p=0.032 for LCT
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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