Anti-Inflammatory Effects of Gomphrenin from Basella alba Fruits
Author Information
Author(s): Rusak Agnieszka, Mrozowska Monika, Kozłowska Weronika, Wiatrak Benita, Dzięgiel Piotr, Wybraniec Sławomir, Carev Ivana, Jama-Kmiecik Agnieszka, Matkowski Adam, Zielińska Sylwia, Bordoni Alessandra
Primary Institution: Wroclaw Medical University
Hypothesis
The gomphrenin-rich fraction from Basella alba L. f. rubra fruits has significant anti-inflammatory and antioxidant properties.
Conclusion
The gomphrenin-rich fraction from Basella alba f. rubra fruits shows potential as an effective anti-inflammatory and antioxidant agent.
Supporting Evidence
- The gomphrenin fraction inhibited pro-inflammatory cytokines IL-1β and IL-6.
- It reduced oxidative stress markers and lipid peroxidation.
- The enriched gomphrenin fraction showed stronger antioxidant effects compared to the crude extract.
- Both extracts inhibited NF-κB and COX activity.
Takeaway
This study found that a special extract from a plant called Basella alba can help reduce inflammation and fight against harmful substances in the body.
Methodology
The study used various assays including SRB, DCF-DA, Griess, MDA, and ELISA to test the anti-inflammatory and antioxidant effects of the gomphrenin-rich fraction and crude extract on human and animal cell models.
Limitations
The study does not address the long-term effects or potential toxicity of gomphrenins with prolonged exposure.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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