Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy
1999
Bcl-2's Role in Blocking Cell Death from Light Therapy
publication
Author Information
Author(s): Granville D J, Jiang H, An M T, Levy J G, McManus B M, Hunt D W C
Primary Institution: QLT PhotoTherapeutics
Hypothesis
Does Bcl-2 overexpression affect the resistance of HL-60 cells to photodynamic therapy?
Conclusion
Bcl-2 overexpression can prevent apoptosis in HL-60 cells during photodynamic therapy, but is less effective at higher drug concentrations.
Supporting Evidence
- Bcl-2 overexpression prevented apoptosis-related events in HL-60 cells.
- Caspase 3 and 6 activation was inhibited by Bcl-2 during photodynamic therapy.
- Bcl-2 was less effective at higher concentrations of the photosensitizer.
Takeaway
Bcl-2 helps keep certain cancer cells alive when treated with light therapy, but it doesn't work as well when the treatment is stronger.
Methodology
The study examined the effects of Bcl-2 overexpression on apoptosis in HL-60 cells treated with a photosensitizer and light.
Participant Demographics
Human acute myelogenous leukaemia HL-60 cells were used in the study.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website