Effects of Oil Palm Phenolics on Gene Expression in Mice
Author Information
Author(s): Leow Soon-Sen, Sekaran Shamala Devi, Sundram Kalyana, Tan YewAi, Sambanthamurthi Ravigadevi
Primary Institution: Malaysian Palm Oil Board
Hypothesis
Oil palm phenolics may have significant biological effects in animals during healthy states.
Conclusion
Oil palm phenolics showed non-toxicity and various beneficial effects in mice, suggesting potential applications as nutraceuticals.
Supporting Evidence
- OPP did not significantly affect organ weights or haematology parameters in mice.
- Gene expression changes indicated potential benefits for cardiovascular health.
- OPP up-regulated genes involved in lipid catabolism and down-regulated cholesterol biosynthesis genes.
Takeaway
This study found that oil palm phenolics are safe for mice and can help improve health by changing how certain genes work.
Methodology
Mice were supplemented with oil palm phenolics and gene expression was analyzed using microarray profiling.
Limitations
The study did not measure the long-term effects of oil palm phenolics or their impact on human health.
Participant Demographics
Male inbred BALB/c mice, aged around five weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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