Study of Genetic and Protein Interactions in Horses with Recurrent Airway Obstruction
Author Information
Author(s): Julien Racine, Vinzenz Gerber, Marybeth Miskovic Feutz, Paige C Riley, Jiri Adamec, June E Swinburne, Laurent L Couetil
Primary Institution: Department of Clinical Veterinary Medicine, Vetsuisse-Faculty, University of Berne
Hypothesis
The study aims to investigate the interactions between candidate genes and proteins in horses affected by recurrent airway obstruction.
Conclusion
The study identifies significant interactions between the IL-4R gene and various proteins, suggesting a complex genetic basis for recurrent airway obstruction in horses.
Supporting Evidence
- The IL-4R gene showed the most interactions with proteins in the study.
- Proteomic analysis identified 277 proteins, with 56 having indirect interactions with IL-4R.
- Four candidate genes were found to have direct interactions with BALF proteins.
Takeaway
This study looks at how certain genes and proteins work together in horses with breathing problems, helping us understand why some horses get sick.
Methodology
The study used genomic and proteomic data from healthy and RAO-affected horses, analyzed through Ingenuity Pathway Analysis software.
Limitations
The study's findings may not be generalizable due to the specific horse populations studied and potential interspecies differences.
Participant Demographics
The study included five RAO-affected horses and six healthy age-matched controls.
Digital Object Identifier (DOI)
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