Quality of Life After Stereotactic Radiosurgery for Brain Metastasis
Author Information
Author(s): Duy Q. Pham, Darrah E. Sheehan, Kimball A. Sheehan, Konstantinos Katsos, Camilo E. Fadul
Primary Institution: University of Virginia School of Medicine
Hypothesis
What are the post-treatment outcomes and quality of life metrics for patients undergoing stereotactic radiosurgery for brain metastases?
Conclusion
Most patients with brain metastasis had no change or improvement in quality of life after stereotactic radiosurgery.
Supporting Evidence
- 34.0% of patients showed improvement in EQ-5D scores after treatment.
- 16.2% of patients had stable EQ-5D scores.
- 35.9% of patients experienced worsening EQ-5D scores.
- Baseline EQ-5D was predictive of EQ-5D single index at final follow-up.
- Patients with stable or improved EQ-5D had significantly higher overall survival.
Takeaway
Doctors used a special treatment called stereotactic radiosurgery to help people with brain tumors, and most of them felt just as good or better afterward.
Methodology
The study analyzed data from the NeuroPoint Alliance SRS Quality Registry, focusing on quality of life metrics and survival outcomes for patients undergoing SRS from 2017 to 2024.
Potential Biases
Data accuracy could not be independently verified at each site, which may introduce bias.
Limitations
The study faced significant attrition and may not fully represent all clinical practices due to variability across participating sites.
Participant Demographics
The median age was 66 years, with 58.2% female, and the most common primary tumor type was lung cancer (61.4%).
Statistical Information
P-Value
0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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