SOFA vs MOD Score in Severe Traumatic Brain Injury
Author Information
Author(s): Zygun David, Berthiaume Luc, Laupland Kevin, Kortbeek John, Doig Christopher
Primary Institution: University of Calgary
Hypothesis
The study aims to compare the discriminative ability of the SOFA and MOD scoring systems regarding hospital mortality and unfavorable neurologic outcomes in patients with severe traumatic brain injury.
Conclusion
The SOFA scoring system is more effective than the MOD scoring system in predicting hospital mortality and unfavorable neurologic outcomes in patients with severe traumatic brain injury.
Supporting Evidence
- SOFA-defined cardiovascular failure was associated with a 14.7 times higher odds of death compared to those without.
- MOD-defined cardiovascular failure was a poor discriminator of hospital mortality.
- SOFA scoring system showed a better area under the ROC curve for predicting outcomes compared to MOD.
Takeaway
This study shows that a scoring system called SOFA is better at predicting how likely patients with severe brain injuries are to survive or recover compared to another system called MOD.
Methodology
A prospective cohort study was conducted at Foothills Medical Centre, including patients aged 16 and older with severe traumatic brain injury and ICU stay longer than 48 hours.
Potential Biases
Potential bias due to non-standardized timing of neurologic outcome assessment and missing data.
Limitations
The study did not record infection acquisition, and there were missing data regarding neurologic outcomes.
Participant Demographics
The cohort included 209 patients, median age 36 years, with 78% male, and various mechanisms of injury.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 5.9–36.3 for SOFA cardiovascular failure
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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