FGFR1 and Muscle Atrophy
Author Information
Author(s): Eash John, Olsen Aaron, Breur Gert, Gerrard Dave, Hannon Kevin
Primary Institution: Purdue University
Hypothesis
Does FGFR1 expression inhibit skeletal muscle atrophy during disuse?
Conclusion
FGFR1 expression can inhibit muscle atrophy and stimulate protein synthesis in skeletal muscle during periods of disuse.
Supporting Evidence
- FGFR1 mRNA expression was significantly increased after 4 days of hind limb suspension.
- Electroporation of FGFR1 significantly inhibited the decrease in muscle fiber area.
- FGFR1 overexpression stimulated protein synthesis in muscle fibers.
Takeaway
When muscles don't get used, they can shrink. This study found that a special protein called FGFR1 can help keep muscles from getting smaller.
Methodology
Mice underwent hindlimb suspension and were treated with FGFR1 plasmid DNA to assess muscle atrophy and protein synthesis.
Limitations
The study was conducted on mice, which may not fully represent human muscle atrophy.
Participant Demographics
Twelve-week-old male mice (AKR/J, Jackson Labs)
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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