Effects of Hypoxia-Reoxygenation in Obstructive Sleep Apnea Patients
Author Information
Author(s): Tansu Ulukavak Ciftci, Oguz Kokturk, Senay Demirtas, Özlem Gülbahar, Neslihan Bukan
Primary Institution: Gazi University Faculty of Medicine
Hypothesis
Hypoxia–reoxygenation phenomena may affect the generation of vascular endothelial growth factor (VEGF), erythropoietin (EPO), endothelin-1 (ENDO-1), and inducible nitric oxide synthase (iNOS).
Conclusion
Hypoxia–reoxygenation phenomena likely affect VEGF and nitrite–nitrate levels, which may contribute to cardiovascular complications in obstructive sleep apnea syndrome (OSAS).
Supporting Evidence
- Serum VEGF levels were significantly higher in OSAS patients than in controls.
- Nitrite-nitrate levels were significantly lower in OSAS patients than in controls.
- After 12 weeks of CPAP treatment, serum VEGF levels decreased in OSAS patients.
- Nitrate levels increased after 12 weeks of CPAP treatment in OSAS patients.
- OSAS is highly prevalent, affecting ≥4% of males and 2% of females.
- Obesity is a significant risk factor for OSAS and cardiovascular complications.
Takeaway
People with sleep apnea have problems with oxygen levels while they sleep, which can affect their heart health. Treating them with a special machine can help improve their oxygen levels.
Methodology
Patients with obstructive sleep apnea were diagnosed using polysomnography, and serum levels of various markers were measured before and after 12 weeks of CPAP treatment.
Potential Biases
Potential bias due to the exclusion of patients with other sleep disorders.
Limitations
The study excluded patients with other sleep disorders and relied on a specific diagnostic criteria for OSAS.
Participant Demographics
The study included 69 patients with OSAS, predominantly middle-aged males, and 17 healthy controls.
Statistical Information
P-Value
P=.003, P=.008, P=.001, P=.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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