Interaction of HERVs with PAMPs in Dysregulation of Immune Response Cascade Upon SARS-CoV-2 Infections
2024
HERVs and Immune Response in COVID-19
publication
Evidence: moderate
Author Information
Author(s): Turčić Marijana, Kraljević Pavelić Sandra, Trivanović Dragan, Pavelić Krešimir, Poggi Alessandro, Cha Hee-Jae
Primary Institution: University of Rijeka
Hypothesis
The study investigates the correlation between the activation of human endogenous retroviruses (HERVs) and the immune response in COVID-19 patients.
Conclusion
The activation of HERVs in response to SARS-CoV-2 may contribute to chronic inflammation and variability in COVID-19 symptoms.
Supporting Evidence
- HERVs can activate immune responses that may lead to chronic inflammation.
- Variability in HERV expression may explain differences in COVID-19 symptoms among patients.
- SARS-CoV-2 spike protein can trigger HERV activation.
- Proinflammatory cytokines released during HERV activation may worsen COVID-19 outcomes.
Takeaway
This study looks at how certain viruses in our DNA can affect our immune response when we get COVID-19, possibly making some people sicker than others.
Digital Object Identifier (DOI)
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