Leptin Receptor Polymorphism and Breast Cancer Risk in Nigerian Women
Author Information
Author(s): Okobia Michael N, Bunker Clareann H, Garte Seymour J, Zmuda Joseph M, Ezeome Emmanuel R, Anyanwu Stanley N, Uche Emmanuel E, Kuller Lewis H, Ferrell Robert E, Taioli Emanuela
Primary Institution: University of Pittsburgh
Hypothesis
The Gln223Arg polymorphism in the leptin receptor gene is associated with breast cancer susceptibility in Nigerian women.
Conclusion
The LEPR Gln223Arg polymorphism is associated with a modestly increased risk of premenopausal breast cancer in Nigerian women.
Supporting Evidence
- Premenopausal women carrying at least one LEPR 223Arg allele had an odds ratio of 1.8 for breast cancer risk.
- There was no significant association found in postmenopausal women.
- The study was conducted in four University Teaching Hospitals in Nigeria.
- Participants included 209 women with breast cancer and 209 controls.
Takeaway
This study found that a specific gene change might make some women more likely to get breast cancer before menopause.
Methodology
A case-control study using PCR-based RFLP assay to evaluate the association between the Gln223Arg polymorphism and breast cancer risk.
Potential Biases
Potential bias due to the use of hospital controls and the absence of a breast cancer screening program in Nigeria.
Limitations
The study used both incident and prevalent cases of breast cancer, which may affect the risk estimation.
Participant Demographics
418 female participants, including 209 with breast cancer and 209 controls, recruited from four University Teaching Hospitals in Nigeria.
Statistical Information
P-Value
0.05
Confidence Interval
1.0–3.3
Statistical Significance
p=0.05
Digital Object Identifier (DOI)
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