1,3,3,5-Tetramethyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
2011
Study of a New Benzodiazepine Compound
publication
Author Information
Author(s): Dardouri Rachida, Rodi Youssef Kandri, Saffon Natalie, Essassi El Mokhtar, Ng Seik Weng
Primary Institution: Laboratoire de Chimie Organique Appliquée, Faculté des Sciences et Techniques Université Sidi Mohamed Ben Abdallah, Fés, Morocco
Hypothesis
The study investigates the reactivity of 1,5-dimethyl-1,5-benzodiazepine-2,4-dione with methyl iodide.
Conclusion
The compound reacted with methyl iodide to yield a di-methylated derivative.
Supporting Evidence
- The seven-membered ring in the compound adopts a boat-shaped conformation.
- The reaction yielded colorless crystals of the di-methylated compound.
Takeaway
Scientists mixed a special chemical with another to create a new version of it, which looks a bit different.
Methodology
The compound was reacted with methyl iodide in a solution of potassium t-butoxide and DMF, and the reaction was monitored by thin layer chromatography.
Digital Object Identifier (DOI)
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