Roles of Planar Cell Polarity Pathways in Neural Tube Defects
Author Information
Author(s): Wu Gang, Huang Xupei, Hua Yimin, Mu Dezhi
Primary Institution: West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
Hypothesis
The study investigates how planar cell polarity (PCP) factors affect the pathogenesis of neural tube defects (NTDs).
Conclusion
The PCP signaling pathway plays a crucial role in neural tube closure, and its disruption is linked to various neural tube defects.
Supporting Evidence
- Neural tube defects are the second most common birth defect in humans.
- PCP signaling is crucial for polarized cell movement and organ morphogenesis.
- Disruption of PCP pathway function is linked to various neural tube defects.
Takeaway
This study looks at how certain signals in cells help the spine and brain form properly during pregnancy, and when these signals don't work, it can lead to birth defects.
Methodology
The review summarizes current understanding of the roles of PCP factors in neural tube closure and their connection to NTDs.
Limitations
The study primarily focuses on genetic and molecular aspects without extensive empirical data from human subjects.
Digital Object Identifier (DOI)
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