Key Role of CPVL and MSR1 in Macrophages for Triple-Negative Breast Cancer Prognosis
Author Information
Author(s): Wang Xinan, Lin Li, Zhang Xue, Zhang Minghui, Sun Zhuo, Yang Yichen, Zhang Xiuna, Yuan Yonghui, Zhang Yong, Chen Hao, Wen Ti
Primary Institution: The First Hospital of China Medical University
Hypothesis
The study investigates the prognostic significance of CPVL and MSR1 expressing macrophages in triple-negative breast cancer (TNBC).
Conclusion
CPVL and MSR1 are potential biomarkers for macrophage-mediated TNBC prognosis, suggesting the therapeutic potential of macrophage targeting in TNBC.
Supporting Evidence
- Macrophages were identified as the most prognostically significant immune cell subpopulation in TNBC.
- CPVL expression was positively correlated with favorable outcomes, while MSR1 was associated with poorer prognosis.
- The study integrated single-cell RNA sequencing with bulk RNA sequencing to clarify the relationship between cells and prognosis.
Takeaway
This study found that certain genes in immune cells, especially macrophages, can help predict how well patients with a specific type of breast cancer will do.
Methodology
The study utilized single-cell RNA sequencing and bulk RNA sequencing, applying Cox regression models to compute hazard ratios and validate prognostic scoring.
Potential Biases
Potential biases may arise from the reliance on specific datasets and the inherent limitations of single-cell sequencing.
Limitations
The study primarily focuses on macrophages and may not fully capture the complexity of the tumor microenvironment.
Participant Demographics
The study analyzed data from 230 TNBC patients.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website