The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors
2011
The Role of P2Y1 Receptor in Sensitivity to Heat and Cold in Nociceptors
Sample size: 135
publication
Evidence: moderate
Author Information
Author(s): Molliver Derek C, Rau Kristofer K, McIlwrath Sabrina L, Jankowski Michael P, Koerber H Richard
Primary Institution: University of Pittsburgh
Hypothesis
P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.
Conclusion
P2Y1 is required for normal thermal signaling in cutaneous sensory afferents.
Supporting Evidence
- P2Y1 knockout mice showed increased heat thresholds and decreased firing rates during thermal stimulation.
- IB4-binding neurons predominantly expressed P2Y1 and responded to the P2Y1 agonist ADP.
- Mechanical sensitivity remained unchanged in P2Y1 knockout mice.
Takeaway
P2Y1 helps our nerves feel hot and cold, and without it, they don't work as well for temperature.
Methodology
The study used ratiometric calcium imaging and intracellular recordings from sensory neurons in an ex vivo preparation.
Limitations
The study primarily focused on male wild type and P2Y1 knockout mice, which may limit generalizability.
Participant Demographics
Adult male wild type and P2Y1 knockout mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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