Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
2011
Presynaptic Ionotropic Receptors and Spike Timing-Dependent Plasticity
publication
Evidence: moderate
Author Information
Author(s): Matthijs B. Verhoog, Huibert D. Mansvelder
Primary Institution: VU University Amsterdam
Hypothesis
How do presynaptic ionotropic receptors influence spike timing-dependent plasticity (STDP)?
Conclusion
Presynaptic ionotropic receptors play a crucial role in modulating the timing rules for synaptic strengthening and weakening.
Supporting Evidence
- Presynaptic ionotropic receptors can influence neurotransmitter release and synaptic plasticity.
- Different types of ionotropic receptors can create specific timing windows for synaptic changes.
- Activation of presynaptic NMDA receptors is crucial for certain forms of synaptic depression.
- Nicotinic acetylcholine receptors can modulate the rules for spike-timing-dependent plasticity.
- Presynaptic receptors may interact with each other to affect synaptic function.
Takeaway
Certain receptors in the brain help decide how and when connections between brain cells get stronger or weaker based on the timing of their activity.
Digital Object Identifier (DOI)
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