Splanchnic Vein Thrombosis in JAK Positive Chronic Myeloproliferative Disorders
Author Information
Author(s): Vladareanu AM, Popov V, Bumbea H, Onisai M, Ilea A, Dobrea C, Miulescu M
Primary Institution: County Emergency Hospital Pitesti Haematology Department
Hypothesis
The presence of JAK2V617F mutation increases the risk for splanchnic thrombosis in patients with chronic myeloproliferative disorders.
Conclusion
Patients were diagnosed with thrombosis of the portal vein before being diagnosed with myeloproliferative neoplasms.
Supporting Evidence
- All patients had homozygous JAK2 mutation, which is associated with increased risk of portal thrombosis.
- Bone marrow biopsy and determination of JAK status are valuable investigations for patients with splenoportal thrombosis.
- The diagnosis of myeloproliferative neoplasms was made after splenectomy in two cases.
Takeaway
Some people with blood disorders can get blood clots in their stomach veins, and a specific gene change makes this more likely.
Methodology
Three patients with portal vein thrombosis were diagnosed with myeloproliferative neoplasms after bone marrow biopsy and JAK2 mutation testing.
Limitations
The study is based on a small sample size of three patients.
Participant Demographics
Three male patients aged 29 to 54 with varying medical histories.
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