Effects of Maternal Androgens on Liver Function in Sheep
Author Information
Author(s): Kirsten Hogg, Charlotte McNeilly, Alan S. Duncan, W. Colin Duncan
Primary Institution: MRC Centre for Reproductive Health, The University of Edinburgh
Hypothesis
Prenatal androgenization affects liver function and metabolism in adult sheep.
Conclusion
Maternal prenatal androgenization leads to fatty liver and altered insulin signaling in young adult sheep, independent of central obesity.
Supporting Evidence
- Maternal testosterone exposure resulted in increased insulin secretion in response to glucose.
- Histological analysis showed fatty liver in offspring exposed to maternal testosterone.
- No changes in body weight or central obesity were observed despite fatty liver presence.
Takeaway
When pregnant sheep are given extra male hormones, their babies can grow up with liver problems, even if they don't get fat.
Methodology
Pregnant ewes received either a control or testosterone propionate treatment, and liver function was assessed in their offspring.
Potential Biases
Potential bias in the interpretation of histological results.
Limitations
The study is limited to sheep and may not directly translate to humans.
Participant Demographics
Young adult sheep, offspring of treated pregnant ewes.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website